FrontAg Nexus is a research initiative funded by the EU under the PRIMA programme. It promotes climate-smart, water-saving frontier agriculture in Mediterranean regions by leveraging innovations like aquaponics, hydroponics, insect farming, vermiculture, and (agro-)photovoltaics. The project applies a Water–Energy–Food–Ecosystem (WEFE) Nexus approach to enhance resilience, food and nutrition security, and socio-economic outcomes for vulnerable communities in countries such as Israel, Italy, Morocco, Tunisia, Turkey, and Jordan.