Kwame Nkrumah University of Science and Technology (KNUST) in Ghana is one of the leading universities of the African continent. After a long-time cooperation in the future-oriented areas of water and energy research, environment, mobility and global health, KNUST and Technical University of Munich (TUM) entered a sustainable and strategic partnership at the end of 2018. KNUST and TUM support existing and new project ideas within a common action framework comprising the key areas of teaching, research, and entrepreneurship. In the long term, this partnership will contribute to a deeper understanding of global challenges and to developing technical and scientific solutions using entrepreneurial approaches.